Département A: Research in Drug Development (RD3)

Unit 1: Microbiology, Bioorganic and Macromolecular Chemistry (MC)

RESEARCH ACTIVITIES

The goals of my research are to provide new insight into protein structure and function, and to decipher how proteins interact together and with other molecules, particularly with pharmacologically active molecules.

TOP 10 RECENT ARTICLES:

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1.

Wintjens et al, 2016 "Global molecular analysis and APOE mutations in a cohort of autosomal dominant hypercholesterolemia patients in France. J. Lipid Res. 2016, 57, 482-91. http://www.ncbi.nlm.nih.gov/pubmed/26802169/

2.

Dupré et al. (2015), Virulence regulation with Venus flytrap domains: structure and function of the periplasmic moiety of the sensor-kinase BvgS." 2015, PloS Pathog 11, e1004700. http://www.ncbi.nlm.nih.gov/pubmed/25738876

3.

Pethe et al 2013. "Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis.", Nat. Med. 19, 1157-60 http://www.ncbi.nlm.nih.gov/pubmed/23913123

4.

Huet et al 2013 "High-resolution structure of a papaya plant-defense barwin-like protein solved by in-house sulfur-SAD phasing. Acta Crystallogr.", D69, 2017-26. http://www.ncbi.nlm.nih.gov/pubmed/24100320

5.

Mbosso et al. "Ceramide, cerebroside and triterpenoid saponin from the bark of aerial roots of Ficus elastica (Moraceae)." Phytochemistry 83, 95-103. http://www.ncbi.nlm.nih.gov/pubmed/22963707

6.

Wintjens et al 2013. "Hypothesis/review the structural basis of sweetness perception of sweet-tasting plant proteins can be deduced from sequence analysis. Plant Sci. 181, 347-54. http://www.ncbi.nlm.nih.gov/pubmed/21889040

7.

Wohlkönig et al 2010 "Structural relationships in the lysozyme superfamily; significant evidence for glycoside hydrolase signature motifs. 2010, PloS One 5, e15388.

8.

Herrou et al 2010. "Periplasmic domain of the sensor-kinase BvgS reveals a new paradigm for the Venus flytrap mechanism. Proc. Natl. Acad. Sci. USA 107, 17351-5. http://www.ncbi.nlm.nih.gov/pubmed/20855615

9.

Huet et al 2008. "X-ray structure of papaya chitinase reveals the substrate binding mode of glycosyl hydrolase family 19 chitinases" Biochemistry 47, 8283-91. http://www.ncbi.nlm.nih.gov/pubmed/18636748

10.

R. Wintjens et al, 2006, "Crystal structure of papaya glutaminyl cyclase; an archetype for plant and bacterial cyclases." J. Mol. Biol., 357, 457-70. http://www.ncbi.nlm.nih.gov/pubmed/16438985

René Wintjens

René WINTJENS

Faculté de Pharmacie

Campus de la Plaine

ULB CP206/04, boulevard du Triomphe, 1050 Bruxelles

Career

2005-ongoing Research Associate at the National Foundation for Scientific Research (F.R.S.-F.N.R.S) at the Free University of Brussels (ULB)

2003-2005: Post-doctoral Researcher at the Free University of Brussels (ULB), Faculty of Pharmacy, service de Chimie Générale (Head: Pr. Y. Looze)

1998-2003: CNRS research engineer at laboratory UMR8525 (Pasteur Institute of Lille) FRANCE (Head: Dr. G. Lippens)

1997-1998: Scientific research worker at the pharmaceutical company SMB Laboratories.

1992-1997: PhD thesis at the Free University of Brussels (ULB) -F.R.I.A GRANT, ULB researcher and Pasteur Institute of Lille grant.