The role of protein tyrosine phosphatases in metabolic diseases

Protein tyrosine phosphatases (PTPs) constitute a superfamily of enzymes that act on tyrosine-phosphorylated proteins. The ULB Center for Diabetes Research has shown that PTPs play a role in pathological conditions such as obesity and inflammation. PTPs should act as molecular switches for key signalling events in the development of metabolic disorders, including obesity and diabetes.
In this proposal, researchers aim to fully characterise the activity and oxidation status of PTPs in metabolic relevant cells, such as pancreatic β-cells and hepatocytes. Importantly, these functions of PTPs make them promising drug candidates for the treatment of metabolic disorders. This research will provide molecular mechanisms to propose novel pre-clinical approaches to treat these pathologies.


Esteban Gurzov

ULB Center for Diabetes Research
Faculty of Medicine

Created on September 19, 2018