Pharmacologie, dopage et éléments d'algologie

• Brief summary of the functional and structural pathways involved in pain: nociception and nociceptive fibres activation, pain afferent pathways (discriminative, affective and motivational components), referred pain, central pain regulatory pathways.
• Description of analgesic drugs targets and mechanisms of action according to the different steps of nociceptive stimuli transduction and modulation: inflammatory reaction (steroidal and non-steroidal anti-inflammatory drugs), muscles (myorelaxant drugs), peripheral nerve (activation, facilitation and propagation), spinal nociceptive neurons (gate control theory), peri-acqueducal grey matter, opoidergic system and high level cortical control (Attentional, limbic and hypothalamic).
• Pragmatic method of analgesic drug selection based on real-life clinical patterns. Red flags in analgesia, sequential drug selection, drugs combinations (positive/negative interactions). Analgesic drugs limitations, number needed to treat (NNT) to get a benefice and combined pharmacological and non- pharmacological treatments.

• Provide a clinical, pragmatical and rational approach of the drugs available to treat acute and chronic musculoskeletal pain

• Ex-cathedra lessons with Power Point slides

Course notes

• Université virtuelle

Campus

Erasme

Method(s) of evaluation

• Oral examination

Oral examination

Language(s) of evaluation

• french
• (if applicable english )