EXPLORE : Contribution of gEnome-wide eXPression profiLes tO the Risk of hEpatocellular carcinoma

 Hepatocellular carcinoma (HCC) is the most frequent form of liver cancer, and the third cause of cancer deaths worldwide. It occurs especially often in patients suffering from liver diseases related, for instance, to alcohol, diabetes and excess weight. HCC is particularly resistant to therapeutic intervention.

Therefore, preventing this cancer in at-risk patients using ‘chemoprevention’ could have a significant impact. However, identifying at-risk individuals is made difficult by the rarity of effective predictive biomarkers.

The EXPLORE project aims to identify gene expression profiles that predispose patients to HCC. Protein markers based on these profiles will enable the development of a blood signature predicting HCC risk, and thus the identification of patients with a high risk of cancer. These markers can also be used to better target chemotherapy, making it possible to offer at-risk patients chemoprevention treatment in order to prevent the development of HCC.

Coordination : Eric Trépo, Laboratoire de gastro-entérologie expérimentale, Faculté de Médecine


Created on September 4, 2020