is known to be erratic and may lead to potential therapeutic failure. The invention relates to 3D printing of this coating method is considered to be erratic and may lead to potential therapeutic failure. It has functionalized capsules by 3D printing to modify the release of drugs. It proposes to substitute the commonly used used to produce unique modified-release e.g. enteric colonic sustained release capsules ready-to-use. production of functionalized capsules by 3D printing used to modify the release of drugs. In pharmaceutical companies printing Caps Delivery systems Licence agreement R D collaboration Priority data EP19166490.3 filed on

treatment options according to the disease progression and monitoring the response to the corresponding therapy stratification of according to stage of transition from steatosis NAFLD NASH to HCC from human biopsies. of PTPs render them highly susceptible to oxidation by ROS to the reversible form of sulfenic acid or Inactivating Protein Tyrosine Phosphatase N2 Gurzov E. N. Tran M. Fernandez-Rojo M. A. Merry T. L. Zhang X. Xu cancer death worldwide with HCC which is refractory to nearly all currently available anti-cancer therapies Hepatocellular carcinoma HCC Obesity Licence agreement R D collaboration PCT WO2022207588A1 Priority date 29

Monomeric flavanol-type compounds are designed to target and reverse HIV latency by inhibiting key proteins formulations to make these compounds more effective and stable offering a new approach to improving HIV HTLV-I and BLV . These features are thought to be due to the transcriptional repression of viral expression goal for HIV-1 is to develop new strategies based on transcriptional mechanisms to reduce the latent Monomeric flavanol-type compounds are designed to target and reverse HIV latency by inhibiting key proteins remains dormant. These reservoirs are a major obstacle to curing HIV as they can reactivate even during treatment Research Tools HIV Clinical Trials License agreement R D collaboration WO2023241799 Priority Date 2022-06-

doctorat portant sur la récupération de métaux précieux Ag Pd Au par des chimies respectueuses de l environnement eutectiques profonds Contrat de licence Collaboration R D Application prioritaire EP23157115.9 Date de priorité

The invention provides methods and tools to implant a durable anchoring system with a single access percutaneous for various applications, from single step stapling to mini-invasive placement of stimulation electrodes pins is designed to be attached on any hollow organs with a single incision procedure to minimise the duration from electrode anchoring to drug delivery or stapling. Highly versatile thanks to its silicone base reshapable focuses on mini-invasive surgery to implant a gastric stimulation device to counter obesity. The multidisciplinary mini-invasive way. The invention provides methods and tools to implant a durable anchoring system with a single for various applications from single step stapling to mini-invasive placement of stimulation electrodes incision laparoscopy Soft tissue Licence agreement R D collaboration Priority application EP18213753 18

site of PTPRK and are amenable to a drug development program further to the validation of their specific with IC50 in the M range amenable to lower concentrations upon hit to lead optimization. In vitro inhibition risk factor for MASLD which can in turn progress to HCC. With an increasing number of patients developing obesity-related liver complications there is a pressing need to develop drugs based on new therapeutic approaches reprogramming and the consequent MASLD. Obesity leads to dysregulated expression of hepatic protein tyrosine Inhibitor Protein Tyrosine Phosphatase Licence agreement R D I collaboration EP 23383162.7 PCT EP2024 082453

possible to stabilize the chemical absorbent which has a higher heat of absorption compared to physical theoretically zero energy losses and allows energy to be stored over very long periods the only technology high temperature thereafter . The invention relates to the development of a composite material based on tested pure or in combination with expanded graphite to improve heat transfer. The invention allows a high Lower reactor corrosion The technology could be used to ensure thermal energy flow regulation and or long-term Long-term storage Chemical process Licence agreement R D collaboration Nomastock EP3161099 Corrostock EP3201285

blades of a wind turbine. The aim of the invention is to propose new devices and methods for detecting the could lead to catastrophic failures. Optical capacitive or resistive sensors are well known to detect icing blades of a wind turbine. The aim of the invention is to propose new devices and methods for detecting the conditions or ice formation and could be coupled to an ice protection system such as electric heater positions on the structure experiencing and driven to heat the structure surface at two different temperatures include thermochromics and hydro chromic devices to sense temperature and moisture in the freestream Ice detection Machine learning Licence agreement R D collaboration Patent pending Publication number

progenitors expressing the NKX2.1 gene give rise to thyroid follicular cells and all cell types of the human embryonic stem cell line genetically modified to overexpress two main thyroid transcription factors of the thyroid organizing them into follicles akin to the native organ. Modifiable culture conditions for the aim of applying an interdisciplinary approach to the study of thyroid pathophysiology the Institute Brussels although the Institute also contributes to the Institut de Biologie Moléculaire et Médicale Drug screening Toxicity studies License agreement R D collaboration Patent filed on 30 11 21 Sabine COSTAGLIOLA

provides means to rapidly provide the most appropriate treatment to the patients according to their risk design of clinical trials so as to assess treatment efficacy according to subgroups of patients. The technology efficient diagnostic methods have been developed to identify COVID-19 infection biomarkers enabling early biomarkers into clinical practice is however needed to recognize COVID-19 patients at risk of severe illness therapeutic antibodies. The present invention is directed to the use of the heptapeptide of angiotensin Ang-1-7 Prognosis COVID-19 Disease Severity Licence agreement R D collaboration EP22153733.5 Priority Date 27 01 2022